Quick answer: In Rejuran vs Juvelook, both are popular Korean skin boosters, but they work differently. Rejuran uses polynucleotides (PN) to repair and calm damaged, thin skin. Juvelook uses PDLLA to stimulate new collagen for firmness, smoother texture and acne scars. Choose Rejuran for skin healing and sensitivity, and Juvelook for collagen and texture.
Key takeaways
- Rejuran is made from salmon-derived PN; Juvelook is PDLLA with hyaluronic acid.
- Rejuran focuses on repair, elasticity and calming the skin.
- Juvelook focuses on collagen building, texture and scars.
- Both usually need a series of sessions a few weeks apart.
- Both are approved by Korea's Ministry of Food and Drug Safety.
What is Rejuran?
Rejuran is a skin booster made by PharmaResearch in Korea. It contains polynucleotides (PN), DNA fragments taken from salmon. When injected in small amounts into the skin, PN supports the skin's own repair process. People choose Rejuran for thin or tired skin, fine lines, enlarged pores, redness, sensitivity and early acne scars. There are versions such as Rejuran Healer, Rejuran i for the eye area and Rejuran S for scars.
What is Juvelook?
Juvelook is a collagen-stimulating injectable made by Vaim Global in Korea. It contains PDLLA (poly-D,L-lactic acid) microspheres mixed with hyaluronic acid. After injection, PDLLA encourages the skin to produce new collagen over several weeks to months. Juvelook is often used for skin texture, enlarged pores, acne scars, fine lines and mild volume loss. Juvelook Volume is a version for deeper volume.
How do Rejuran and Juvelook compare?
- Main ingredient: Rejuran PN; Juvelook PDLLA with HA.
- Main action: Rejuran repair and regeneration; Juvelook collagen stimulation.
- Best for: Rejuran for thin, sensitive or damaged skin; Juvelook for texture, scars and firmness.
- Sessions: Rejuran often 2 to 4; Juvelook often 2 to 3, a few weeks apart.
- Downtime: Rejuran small bumps for a day or two; Juvelook small bumps and possible swelling for a few days.
- How long results last: Rejuran often several months; Juvelook often longer, as collagen builds.
Which is better for sensitive or damaged skin?
Rejuran is often the better choice for skin that is red, sensitive, dry or recovering from lasers or acne. PN supports healing and helps the skin barrier feel stronger. Many people in Korea use Rejuran as a regular treatment to keep skin calm and healthy.
Which is better for texture and acne scars?
Juvelook is often the better choice for uneven texture, enlarged pores and rolling acne scars. As collagen forms, the skin becomes thicker and smoother. Results build slowly, so patience is needed, but the improvement can last longer.
Can you combine Rejuran and Juvelook?
Yes. Some doctors combine them in the same session or alternate sessions. Rejuran supports healing and skin quality, while Juvelook builds collagen. This can be useful for people with both sensitivity and texture concerns. They also pair well with lasers and lifting devices.
What is the downtime?
After Rejuran, small raised bumps appear at the injection points and usually settle within a day or two. After Juvelook, bumps can last a few days, and mild swelling is possible. Small bruises can occur with both. Most people return to normal plans the next day.
Is it safe?
Both are approved in Korea and are safe when injected by trained doctors. Possible side effects include redness, bumps, bruising and, rarely, small lumps or infection. Tell your doctor if you have a fish allergy, as Rejuran is derived from salmon DNA.
How to choose
Korea treated about 2.01 million foreign patients in 2025, and around 63% came for dermatology, according to the Ministry of Health and Welfare. Skin boosters are among the treatments visitors ask about most. Your choice depends on whether your main concern is skin health and sensitivity or texture and collagen.
Frequently asked questions
Which works faster?
Rejuran often shows a glow within a few weeks; Juvelook builds more slowly over months.
Does Juvelook add volume?
Standard Juvelook adds little volume. Juvelook Volume is designed for deeper volume.
Can I do them before a trip home?
Yes, but allow a day or two for bumps to settle.
How often should I repeat?
Usually a series first, then maintenance every few months.
Sources
- Ministry of Health and Welfare, Republic of Korea – 2025 foreign patient statistics (press release, 2026).
- Ministry of Food and Drug Safety, Republic of Korea – medical device approval information (Rejuran; Juvelook).
- PharmaResearch – Rejuran product information; Vaim Global – Juvelook product information.
This article is for general information only and is not medical advice. Results vary between individuals. Please consult a qualified physician before any treatment.
