Quick answer: In Rejuran vs Profhilo, both improve skin quality but in different ways. Rejuran uses polynucleotides (PN) to repair damaged, thin or sensitive skin. Profhilo uses a high concentration of hyaluronic acid that spreads under the skin to hydrate and improve laxity. Choose Rejuran for repair and texture, and Profhilo for hydration and mild skin laxity.
Key takeaways
- Rejuran is PN from salmon DNA; Profhilo is pure hyaluronic acid.
- Rejuran supports healing; Profhilo hydrates and supports skin firmness.
- Profhilo uses few injection points; Rejuran uses many small injections.
- Both usually start with two or more sessions a few weeks apart.
- They can be combined for repair and hydration.
What is Rejuran?
Rejuran is a skin booster made by PharmaResearch in Korea. It contains polynucleotides (PN), DNA fragments from salmon. Injected in small amounts across the face, PN supports the skin's natural repair process. It is popular for thin or tired skin, fine lines, enlarged pores, redness, sensitivity and early acne scars.
What is Profhilo?
Profhilo is an injectable made by IBSA in Italy. It contains a high concentration of both high and low molecular weight hyaluronic acid, made with a heat process instead of chemical cross-linking. It is injected at a small number of points on each side of the face, and the gel spreads under the skin. This hydrates the skin and is described as bio-remodelling, helping improve mild laxity and skin quality. It does not add volume like a filler.
How do Rejuran and Profhilo compare?
- Main ingredient: Rejuran PN; Profhilo hyaluronic acid.
- Main action: Rejuran repair and regeneration; Profhilo hydration and bio-remodelling.
- Injection points: Rejuran many small points; Profhilo about five points per side.
- Best for: Rejuran for damaged or sensitive skin and pores; Profhilo for dry, crepey skin and mild laxity.
- Sessions: Rejuran often 2 to 4; Profhilo usually 2 sessions about four weeks apart.
- Downtime: Rejuran small bumps for a day or two; Profhilo small bumps for several hours to a day.
Which is better for texture and pores?
Rejuran is often the better choice for uneven texture, enlarged pores, redness and early acne scars. The many small injections treat the skin evenly, and PN supports healthier skin over a series of sessions.
Which is better for hydration and mild laxity?
Profhilo is often the better choice for skin that looks dry, thin or slightly loose, especially in people in their late 30s and older. Its high HA content hydrates deeply and can make the skin look firmer and more radiant. It is also used on the neck.
Can you combine Rejuran and Profhilo?
Yes. Some doctors combine them in a plan, using Profhilo for hydration and firmness and Rejuran for repair and texture. They may be done on the same day or a few weeks apart. Both also work well with lasers and lifting treatments.
What is the downtime?
After Rejuran, small bumps appear at the injection points and usually settle within a day or two. After Profhilo, small raised bumps at the injection points usually disappear within hours to a day. Bruising is possible with both. Most visitors return to sightseeing quickly.
Is it safe?
Both are widely used and safe when injected by trained doctors with genuine products. Possible side effects include redness, swelling, bumps and bruising. Rare risks include infection. Tell your doctor about fish allergies before Rejuran.
How to choose
Korea treated about 2.01 million foreign patients in 2025, and around 63% came for dermatology, according to the Ministry of Health and Welfare. Skin quality treatments are a key reason visitors come. Your choice depends on whether your skin needs repair, hydration or both, and how much time you have in Seoul.
Frequently asked questions
Is Profhilo a filler?
No. It is hyaluronic acid, but it spreads under the skin to hydrate rather than add volume.
Which is less painful?
Profhilo uses fewer injection points; Rejuran uses many but with numbing cream.
How long do results last?
Both often last several months after the first course, then maintenance is needed.
Can I use either on the neck?
Yes. Both can be used on the neck as well as the face.
Sources
- Ministry of Health and Welfare, Republic of Korea – 2025 foreign patient statistics (press release, 2026).
- Ministry of Food and Drug Safety, Republic of Korea – medical device approval information (Rejuran).
- PharmaResearch – Rejuran product information; IBSA – Profhilo product information.
This article is for general information only and is not medical advice. Results vary between individuals. Please consult a qualified physician before any treatment.
