Quick answer: For fine lines, Rejuran repairs thin, tired skin with polynucleotides (PN) so fine lines from dryness and damage soften over a series. Skin Botox places tiny, diluted doses of botulinum toxin in the upper skin to smooth texture, reduce oil and shrink the look of pores. Choose Rejuran for crepey fine lines, and skin Botox for oily skin, pores and a smooth finish.
Key takeaways
- Rejuran improves skin quality and elasticity; skin Botox smooths the surface.
- Skin Botox is different from regular wrinkle Botox in the muscles.
- Skin Botox can reduce oil and the look of pores for a few months.
- Rejuran needs a series; skin Botox is often a single session.
- Many people combine both for smooth, healthy-looking skin.
What causes fine lines?
Fine lines are small, shallow lines in the skin. They often come from dryness, sun damage, thinning skin and the loss of collagen with age. Some fine lines also come from small muscle movements under the skin. The best treatment depends on the cause: skin quality, muscle activity or both.
What is Rejuran?
Rejuran is a skin booster made by PharmaResearch in Korea. It contains polynucleotides (PN), DNA fragments from salmon, injected in small amounts across the skin. PN supports skin repair and elasticity, which can soften fine lines caused by thin or damaged skin. It also helps pores, redness and texture. Most people have two to four sessions a few weeks apart.
What is skin Botox?
Skin Botox, sometimes called micro Botox or Dermotoxin, uses very diluted botulinum toxin injected in many tiny points into the upper layer of the skin rather than deep into muscles. It relaxes small muscle fibres and reduces sweat and oil gland activity. This can smooth fine texture, reduce shine and make pores look smaller. It does not freeze facial expressions when done correctly.
How do Rejuran and skin Botox compare?
- Main action: Rejuran repair and elasticity; skin Botox surface smoothing and oil control.
- Best for: Rejuran for dry, thin or crepey fine lines; skin Botox for oily skin, pores and a smooth finish.
- Sessions: Rejuran often 2 to 4; skin Botox often one session.
- When results show: Rejuran gradually over weeks; skin Botox within about one to two weeks.
- How long it lasts: Rejuran several months after a series; skin Botox about three to four months.
- Downtime: Rejuran small bumps for a day or two; skin Botox small bumps for a few hours.
Which is better for crepey or dry fine lines?
Rejuran is often the better choice when fine lines come from thin, dry or sun-damaged skin. By supporting repair and elasticity, it makes the skin itself healthier, so lines look softer and the skin looks more rested.
Which is better for pores and oily skin?
Skin Botox is often the better choice if you have oily skin, visible pores or a rough texture on the cheeks and forehead. It can give a smooth, matte finish that many people like before events. It is also used on the neck and jawline to smooth fine lines and improve contour.
Can you combine Rejuran and skin Botox?
Yes. This is a popular combination in Korea. Rejuran repairs and strengthens the skin, and skin Botox smooths the surface and controls oil. They can be done on the same day or in separate sessions. They also pair well with laser toning.
What is the downtime?
After Rejuran, small raised bumps usually settle within a day or two. After skin Botox, tiny bumps usually fade within a few hours. Small bruises are possible with both. Most visitors return to normal plans the same or next day.
Is it safe?
Both are safe when done by trained doctors with genuine products. Skin Botox must be placed carefully to avoid affecting expression. Rejuran side effects include bumps, redness and bruising. Tell your doctor about fish allergies before Rejuran.
How to choose
Korea treated about 2.01 million foreign patients in 2025, and around 63% came for dermatology, according to the Ministry of Health and Welfare. Fine lines and pores are common concerns among visitors. Choose based on what causes your lines, and your doctor can combine treatments if needed.
Frequently asked questions
Is skin Botox the same as regular Botox?
It uses the same type of product, but it is diluted and placed in the upper skin, not deep in the muscles.
Will skin Botox change my expressions?
When done correctly, no. It targets the skin surface.
Which works faster?
Skin Botox usually shows results within about one to two weeks.
Can I combine them on one trip?
Yes. Many visitors have both in one visit.
Sources
- Ministry of Health and Welfare, Republic of Korea – 2025 foreign patient statistics (press release, 2026).
- Ministry of Food and Drug Safety, Republic of Korea – approval information (Rejuran; botulinum toxin products).
- American Academy of Dermatology – botulinum toxin information.
This article is for general information only and is not medical advice. Results vary between individuals. Please consult a qualified physician before any treatment.
