Quick answer: In Xeomin vs Botox, both are FDA-approved botulinum toxin type A products that relax muscles and soften expression lines. The main difference is formulation: Xeomin is a purified toxin without complexing proteins, while Botox contains these accessory proteins. For most people, results, onset and duration are very similar when each is dosed correctly.
Key takeaways
- Xeomin is incobotulinumtoxinA by Merz; Botox is onabotulinumtoxinA by Allergan.
- Xeomin has no complexing proteins, so it is often called a pure or naked toxin.
- Units are broadly similar, but your doctor sets the exact dose.
- Xeomin can be stored at room temperature before mixing.
- Both usually last about three to four months on the face.
What is Botox?
Botox is onabotulinumtoxinA made by Allergan Aesthetics. It contains the active botulinum toxin along with complexing proteins that surround it. It was first FDA-approved for frown lines in 2002 and is now approved for several facial lines. It is the most widely studied product of its type.
What is Xeomin?
Xeomin is incobotulinumtoxinA made by Merz Aesthetics. It was FDA-approved for frown lines in 2011 and later for other uses. During manufacturing, the complexing proteins are removed, leaving only the active toxin. Because of this, Xeomin is sometimes described as a purified or naked toxin. It does not need refrigeration before it is reconstituted.
How do Xeomin and Botox compare?
- Formulation: Xeomin without complexing proteins; Botox with complexing proteins.
- Units: broadly comparable, though doctors adjust for each person.
- Onset: both usually start within about three to five days, with full effect around two weeks.
- Duration: both usually about three to four months for expression lines.
- Storage: Xeomin can be stored at room temperature before mixing; Botox is refrigerated.
- Approval: both FDA-approved for frown lines.
Why do complexing proteins matter?
Complexing proteins do not help smooth wrinkles. Some experts think that, in rare cases, the body can form antibodies to botulinum toxin, which may reduce how well future treatments work. A formulation without complexing proteins may lower this theoretical risk. This is most relevant for people who need high doses or very frequent treatments.
Who might prefer Xeomin?
Xeomin may suit people who have had many treatments over the years and want to reduce exposure to extra proteins, or those whose results seem to be getting weaker. It is also a good option for anyone who simply wants a purified product.
Who might prefer Botox?
Botox may suit people who have had good results with it before and want consistency. It has the longest track record and a huge amount of research. Many doctors know its spread and dosing very well.
What about Korean botulinum toxins?
Korea has several local products approved by the Ministry of Food and Drug Safety, and some are made with reduced complexing proteins. They are widely used for jaw slimming, skin Botox and wrinkles. Ask which product the clinic uses for each area.
How long do results last?
For most people, results from both last about three to four months for forehead lines, frown lines and crow's feet. Jaw slimming often lasts longer, around four to six months. Muscle strength, metabolism and dose all affect how long the effect stays.
What is the downtime?
Downtime is minimal. Small bumps fade within an hour, and small bruises are possible. Avoid pressing or massaging the area, lying flat and intense exercise for a few hours afterwards.
Is it safe?
Both are safe when used by trained doctors. Possible side effects include bruising, headache and, rarely, a drooping brow or eyelid. These usually improve within weeks. Tell your doctor about pregnancy, breastfeeding or neuromuscular conditions.
How to choose
Korea treated about 2.01 million foreign patients in 2025, and around 63% came for dermatology, according to the Ministry of Health and Welfare. Botulinum toxin is one of the most popular treatments for visitors. Accurate dosing and placement matter more than the brand for most people.
Frequently asked questions
Is Xeomin better than Botox?
Not necessarily. Results are similar; the main difference is the formulation.
Can I switch from Botox to Xeomin?
Yes. Your doctor will adjust the dose as needed.
Does Xeomin work faster?
Onset is similar, usually within a few days.
What if Botox stopped working for me?
Discuss it with your doctor. A purified toxin may be considered.
Sources
- Ministry of Health and Welfare, Republic of Korea – 2025 foreign patient statistics (press release, 2026).
- U.S. Food and Drug Administration – approval information (Xeomin; Botox Cosmetic).
- Ministry of Food and Drug Safety, Republic of Korea – botulinum toxin product approval information.
This article is for general information only and is not medical advice. Results vary between individuals. Please consult a qualified physician before any treatment.
